Amputation
Surgical removal of a limb or portion of a limb. Above knee, below knee, or partial foot are all varieties.

Aorta
The largest artery in the body, originating at the left ventricle and serving as the primary trunk from which the entire arterial system proceeds.

Atherosclerosis
The process within the arteries where deposits of fatty substances, cholesterol, calcium or fibrin are built up in the inner lining.

Artery
A blood vessel carrying oxygen-rich blood from the heart to the rest of the body. When diseased, the area supplied may become damaged due to lack of oxygen and nutrients.

Blood Pressure
The force of blood pushing against blood vessel walls.

Bypass Surgery
This is a type of surgery that reroutes, or "bypasses", blood around clogged arteries to improve blood flow and oxygen to the body.

Calcium
A mineral found mainly in the hard part of bones. Calcium is essential for healthy bones. It is also important for muscle contraction, heart action, nervous system maintenance, and normal blood clotting.

Catheter
A tiny flexible tube that can be inserted into a blood vessel.

Critical Limb Ischemia
A severe obstruction of the arteries which seriously decreases blood flow to the extremities (hands, feet and legs) and has progressed to the point of severe pain and even skin ulcers or sores. Critical Limb Ischemia (CLI) is often present in individuals with severe peripheral arterial disease (PAD).

Circulatory System
The system that moves blood throughout the body. The circulatory system is composed of the heart, arteries, capillaries, and veins. This system transports oxygenated blood from the lungs and heart throughout the body via the arteries. And the blood that has been depleted of oxygen by the body is then returned to the lungs and heart via the veins.

Diabetes
A metabolic disorder in which the body does not produce insulin (type 1) or when the body does not make enough or cannot properly use insulin (type 2).

Endovascular
A form of minimally invasive surgery that was designed to access many regions of the body via major blood vessels.

Femoral Arteries
The large arteries in legs, which extends from hip to knee.

Gangrene
Tissue death caused by poor blood flow. It is usually black with color, often with a foul odor.

High Blood Pressure
When the pressure in the arteries is consistently above the normal range. Also known as hypertension.

Homocysteine
An amino acid found in blood.

Iliac Arteries
Two large arteries that split from the aorta in the pelvic region and carry blood to the lower limb.

Intermittent Claudication
Discomfort or pain that occur when the leg muscles do not receive the oxygen rich blood required during exercise, thus causing cramping in the hips, thighs or calves.

Interventional
Pertaining to the act of intervening, interfering or interceding with the intent of modifying the outcome.

Ischemia
An organ (heart, brain, kidneys, or foot, for example) that is not getting adequate blood flow and lacks vital oxygen and nutrients.

Minimally Invasive Procedure
A minimally invasive procedure is any procedure (surgical or otherwise) that is less invasive than open surgery used for the same purpose.

Non-ablative
Without removing tissue

Peripheral Arterial Disease (PAD)
A common disorder that occurs in the artery segments of the circulatory system (legs, pelvis, neck brain). The artery wall linings slowly become narrowed and rough clots formed due to built up cholesterol or plaque. It has major implications on a patient's life due to association with blockages in the heart and brain with potential for death from heart attack and stroke.

Plaque
The built up material on the inner lining of an artery made up of cholesterol, calcium and fibrous tissue.

Popliteal Arteries
Blood vessels that run behind the knees.

SFA
Superficial femoral artery. Blood vessel located in the thigh.

Stenoses
Constriction or narrowing of an artery.

Tibial Arteries
Blood vessels that provide blood to the smaller arteries of the feet and toes.

Ulcers
Sore that develops on the legs, feet or toes as a result of poor circulation.

Vessels
The tube like structures in the circulatory system that are responsible for circulating blood within the body. The three kinds of vessels are arteries, veins and lymphatics. Capillaries are the microscopic structures that connect arteries and veins at the tissues.